On July 16, 2017, DeChambeau earned his first PGA Tour victory by winning the John Deere Classic by a single stroke over Patrick Rodgers. He carded a round of 65 in the final round to win his maiden title in his 40th start on tour. The win coming the week before, gained DeChambeau a place in the 2017 Open Championship, where he missed the cut after rounds of 76–77 (+13).
On June 3, 2018, DeChambeau won the Memorial Tournament in Dublin, Ohio, in a sudden-death playoff against Kyle Stanley and An Byeong-hun, after the three finished regulation play tied at −15. After Stanley bogeyed the first hole of sudden death, DeChambeau then proceeded to win with a birdie on the second hole, giving him his second win on the tour.
Born in Modesto, California, to John Howard Aldrich DeChambeau and Janet Louise Druffel, DeChambeau moved to Clovis, east of Fresno, at age seven. He attended Clovis East High School and won the California State Junior Championship at age 16 in 2010. DeChambeau graduated in 2012 and accepted a scholarship to Southern Methodist University in Dallas, Texas, majoring in physics.