On 23 November 2011, Lowry was again loaned out to play in the Championship, this time to Millwall until 3 January 2012. He followed Aston Villa team-mate Nathan Baker who also signed on loan for Millwall two days earlier. Lowry made his Millwall debut three days later, where he played 90 minutes, in a 0–0 draw against Crystal Palace. His impressive display at Millwall soon earned a loan extension. Weeks later on 13 January 2012, Lowry was sent-off in the 22nd minutes after stamping on Nikola Žigić, which saw Millwall lose 6–0. Three years on after signing for Birmingham City, Lowry stated, quoting: "Whatever club I play for I fully commit to that club at the time. I play with my heart on my sleeve. Sometimes in the past I have gone overboard but I was a younger player then, I have learned a lot from these types of experiences. But I am an aggressive player, that’s the way I like to play and I can’t change the way I play. I will use my experience now and be a bit more clever."'
On June 16, Fowler carded a round of 65 at Erin Hills to take the first round lead at the 2017 U.S. Open. Fowler equaled the lowest first round score at the U.S. Open and led by one stroke from Paul Casey and Xander Schauffele. He followed this up with a one over par 73 in the second round to fall out of the lead by one stroke, held by four other players. He shot 68-72 over the weekend to finish in a tie for fifth place. This gave Fowler his sixth top-5 finish in a major, but he is still yet to win. Fowler started the PGA Championship with a 2-under 69 which was two strokes behind the leaders. After rounds of 70-73, he closed out the year's last major with a 4-under 67, including a run of four consecutive birdies on holes 12 through 15. Despite his solid finish, Fowler ended up tied for fifth and was 3 strokes behind the winner, and friend, Justin Thomas. It was his seventh top-5 major finish, meaning he's had multiple top-5 finishes at every major.
In 2008, Fowler repeated as Sunnehanna Amateur champion. In the first round of the U.S. Open, Fowler shot a −1 (70) and was in a tie for 7th place. He was one of three amateurs to make the cut, along with Derek Fathauer and Michael Thompson. He ended the tournament tied for 60th. In October 2008 Fowler played on the Eisenhower Trophy team that finished second. He was the leading individual player.
After finishing fifth in the Hyundai Tournament of Champions in Hawaii, Fowler claimed his first victory of 2016 in the Abu Dhabi HSBC Golf Championship on the European Tour. He shot a final round of 69 to finish one clear of Belgium's Thomas Pieters. Two weeks later, Fowler was in contention to win again but lost out to Japan's Hideki Matsuyama in a playoff at the Waste Management Phoenix Open. On March 7, Fowler sparked fantastic scenes after sinking a hole-in-one with fellow tour pro Luke Donald's pitching wedge to win $1 million for Ernie Els' charity, Els for Autism.
The Open Championship: Enjoyed his best finish among seven major championship starts, with a T5 at The Open Championship at Royal St. George's. Opened with three par-or-better rounds to enter the final round three strokes behind Darren Clarke. Closed with a 2-over 72 in windy conditions to finish tied with fellow Americans Chad Campbell and Anthony Kim.
2019 Open Champion Shane Lowry, compared to Tommy Fleetwood, is on the other side of the spectrum in regards to brand loyalty. He is Cleveland/Srixon in 12 clubs including the ball with the only two exceptions being the TaylorMade M4 3-wood and his Odyssey Putter. In this case, that makes sense, those clubs seem to be a challenge to swap, especially the 3-wood, and Cleveland/Srixon isn’t really known for putters on the PGA Tour.
Frys.com Open: At the Frys.com Open in Scottsdale, Ariz., reached a three-way playoff with Jamie Lovemark and eventual-winner Troy Matteson. Began the final round four strokes behind Matteson, but played his first five holes in 5-under, punctuated by a hole-in-one from 211 yards at the par-3 fifth hole. After finishing T2 in the playoff, he had recorded all eight of his professional rounds in the 60s. Thanks to the T7 in Las Vegas at the Justin Timberlake Shriners Hospitals for Children Open and T2 finish at Grayhawk GC, he surpassed No. 150 from the 2008 money list, earning special temporary membership on TOUR for the remainder of the season.
Lowry made his professional debut in the 2009–10 UEFA Europa League in an away fixture at Rapid Vienna. On 17 September 2009, Lowry signed a three-month loan deal with Football League Championship side Plymouth Argyle. Lowry made his Plymouth Argyle debut on 19 September 2009, playing 90 minutes, in a 3–1 loss against Newcastle United. He played 13 league games for Plymouth during his loan spell, where he impressed many and was recalled by Villa who required Lowry's services as cover after some injuries to defenders.