In September, he signed a clothing deal with Puma. In the same month, he was also chosen as a captain's pick for the U.S. Ryder Cup team. At age 21 years and 9 months when the matches began, Fowler became the youngest U.S. Ryder Cup player of all time, and only European Sergio García was younger when he made his Ryder Cup debut in 1999. Fowler forfeited a hole during foursomes competition on the first match day because of a rules violation, by taking a permissible free drop from muddy conditions in an improper location, a mistake U.S. captain Corey Pavin attributed to Fowler's inexperience. On the final day of the competition in his singles match against Edoardo Molinari, Fowler birdied the last 4 holes to halve the match after having been 4 down after 12 holes.
In May 2012, Fowler won the Wells Fargo Championship in Charlotte on the first extra hole of a sudden-death playoff. Replaying the 18th hole, he defeated Rory McIlroy and D. A. Points with a birdie to gain his first PGA Tour win. Fowler shot a 69 (−3) in the final round to finish in a three-way tie after 72 holes at Quail Hollow Club. This win enabled Fowler to break the top-25 in the world, placing him at number 24. The following week at The Players Championship in Ponte Vedra Beach, Florida, Fowler played the final hole at −11 under par and had a birdie opportunity to bring him within one of leader and eventual winner Matt Kuchar. Fowler, however, pushed his putt to the right and finished in a tie for second, the fifth second-place finish of his career.
Lowry was the 2007 Irish Amateur Close Champion, defeating Niall Turner 4 & 3 in the final. While still an amateur in May 2009, he won The Irish Open on the European Tour, defeating Robert Rock on the third hole of a sudden death playoff. The win, on his tour début, made him just the third amateur to win on the European Tour, following Danny Lee earlier in the 2009 season, and Pablo Martín in 2007. Lowry shot a 62 to equal the lowest ever by an amateur on the circuit and led from the second round onwards.