Advanced to the FedExCup Playoffs and TOUR Championship for the second consecutive season, finishing No. 23 in the FedExCup. Victory at the CareerBuilder Challenge marked his second career PGA TOUR title and one of five top-10s in a season where he made 16 cuts in 20 starts. Also won on the European TOUR. Reached as high as No. 2 in the Official World Golf Ranking. Earned a spot on the Ryder Cup European team for the first time.

On April 14, Schauffele tied for second in the Masters Tournament, one stroke behind champion Tiger Woods. After opening with a 1-over 73, recorded rounds of 65-70-68 to finish T2 at the Masters Tournament with Dustin Johnson and Brooks Koepka. Schauffele's finish at the Masters Tournament represented his third top-five in eight starts at major championships (T5 at 2017 U.S. Open, T2 at 2018 Open Championship, T2 at 2019 Masters Tournament). He led the field with 25 birdies, becoming the third player since 1980 to have 25 or more birdies in a single Masters, joining Phil Mickelson (25 in 2001) and Jordan Spieth (28 in 2015).[25]