Surgery: Pulled out of next two PGA TOUR starts, the Genesis Open and The Honda Classic. Released statement: "My doctors have advised me not to play the next two weeks, to continue my treatment and to let my back calm down. This is not what I was hoping for or expecting. I am extremely disappointed to miss the Genesis Open, a tournament that benefits my foundation, and The Honda Classic, my hometown event. I would like to thank Genesis for their support, and I know we will have an outstanding week." In April, announced on his website he had undergone further back surgery. The operation was performed by Dr. Richard Guyer of the Center for Disc Replacement at the Texas Back Institute.
World Golf Championships-CA Championship: Logged 56th career TOUR victory and 13th official World Golf Championships title in 24th start at the CA Championship at Doral Golf Resort & Spa. Held the 36- and 54-hole leads before closing out a two-stroke win over Brett Wetterich, marking the 39th time winning (in 42 events) when holding at least a share of the third-round lead.

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Ford Championship at Doral: Took over as World No. 1 for the first time since the week of Aug. 30, 2004 by defeating Phil Mickelson by a stroke at the Ford Championship at Doral. Paired with Mickelson in the final round for just the third time in his career, began the day two strokes behind. Caught up to Mickelson at the turn and took a two-stroke lead after an eagle on the par-5 12th hole. Mickelson birdied the next two and both bogeyed the 16th to remain tied with two holes to play. Birdied the 17th hole and when Mickelson's chip on No. 18 lipped out, earned the 42nd victory of his career.
Won seven times en route to capturing the inaugural FedExCup, cruising through the PGA TOUR Playoffs for the FedExCup with two wins and a T2 in three starts. Captured 13th career major championship (second all-time to Jack Nicklaus' 18) and finished the year with 61 official PGA TOUR victories, fifth all-time. Adjusted scoring average was 67.79, matching own record set in 2000. With 60 official rounds, won his seventh career Vardon Trophy and also captured the Byron Nelson Award. 
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